Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects
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چکیده
منابع مشابه
Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects
Detection and repair of radiation-induced DNA damage occur in the context of chromatin. An intricate network of mechanisms defines chromatin structure, including DNA methylation, incorporation of histone variants, histone modifications, and chromatin remodeling. In the last years it became clear that the cellular response to radiation-induced DNA damage involves all of these mechanisms. Here we...
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BACKGROUND Radiation-induced alterations in posttranslational histone modifications (PTMs) may affect the cellular response to radiation damage in the DNA. If not reverted appropriately, altered PTM patterns may cause long-term alterations in gene expression regulation and thus lead to cancer. It is therefore important to characterize radiation-induced alterations in PTM patterns and the factor...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2012
ISSN: 2234-943X
DOI: 10.3389/fonc.2012.00117